An aberrant sugar modification of BACE 1 blocks its lysosomal targeting in A lzheimer's disease
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چکیده
منابع مشابه
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). However, there is a concern that inhibiting BACE1 could also affect several physiological functions. Here, we show that BACE1 is modified with bisecting N-acetylglucosamine (GlcNAc), a sugar modification highly e...
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(Note: With the exception of the correction of typographical or spelling errors that could be a source of ambiguity, letters and reports are not edited. The original formatting of letters and referee reports may not be reflected in this compilation.) Thank you for the submission of your manuscript to EMBO Molecular Medicine. In this case we experienced unusual difficulties in securing three wil...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2015
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201404438